Clear out old, decaying cells for optimum function
Quercetin is a natural flavonoid with a potent ability to clear out senescent cells from the body. As we age, large numbers of old (or senescent) cells linger throughout tissues in the body. Quercetin helps clear out the remains of those decaying zombie cells, acting as a detoxifying agent and improving the overall function of the body. Moreover, Quercetin intake is associated with better cardiovascular health, enhanced kidney function and decreased inflammation as well a decline in harmful reactive oxygen species (ROS or free radicals that damage your cells).
Why do you need to clear your senescent cells?
As well as accumulating as we age, these senescent, zombie cells stop dividing and instead secrete inflammatory signals that turn neighbouring cells into zombie cells too. As we age, inflammation in all tissues increases and the inflammatory signals the senescent cells secrete contribute to this, leading to multiple diseases such as rheumatoid arthritis. Quercetin has senolytic action, meaning it is capable of killing senescent cells, so it acts as an anti-inflammatory compound to help fight inflammation and prevent these diseases.
How does quercetin benefit the cardiovascular system?
As a bioflavonoid, quercetin has multiple health benefits including supporting cardiovascular health. Cardiovascular disease is still the leading cause of death for both men and women, accounting for an estimated 17.9 million lives each year, which makes up 32% of all deaths worldwide, according to the World Health Organisation (WHO). So prioritising cardio health is vital. Increasing your quercetin intake has been shown to be linked to a decrease in cardiovascular diseases and protects against oxidative stress, cardiotoxicity and heart failure.
Quercetin as an anti-allergen
Quercetin also removes free radicals from the body, enabling it to act as an antihistamine and strengthen antioxidant defence systems in the body. By acting as an anti-inflammatory agent, quercetin can also help maintain a healthy respiratory tract for seasonal allergy sufferers. Combine that with Vitamin C (which our Quercetin formula already contains!), and you increase your chances of maintaining a healthy immune system, while keeping inflammation at bay. Quercetin is shown to activate the anti-oxidant pathway called NRF2, which has been characterised as the major mechanism that protects our bodies from damaging reactive oxygen species.
NAD+ is a molecule present in every living cell and vital to healthy ageing. The decline of NAD+ is one of the biggest causes of ageing and the presence of CD38, a glycoprotein molecule, contributes to NAD+ loss more than anything else. Quercetin is an efficient CD38 inhibitor - by reducing CD38 production, taking quercetin has been shown to directly increase NAD+ levels to support your healthy ageing.
Quercetin human clinical trials
Quercetin has been proven safe in high doses up 1000mg to in human clinical studies, with a high number of studies showing no or few adverse effects and/ or toxicity.
In one study, 84 patients with idiopathic hypertension and gout took 1000mg quercetin twice a day for 6 months and then 500mg twice a day for another 6 months (12 months in total). Results showed improvement of cardiac diastolic function, purine metabolism, renal function and normalization of blood pressure.
Another study saw 50 women with rheumatoid arthritis who took 500mg quercetin a day for 8 weeks display lower plasma levels and lessened pain.
Why are there Vitamin C and citrus bioflavonoids in this Quercetin formula?
Vitamin C prevents the oxidation of Quercetin, ensuring that it stays in it’s reduced form, which in turn makes Quercetin more efficient as an antioxidant, while boosting it’s bioavailability. Vitamin C is found in nature in the presence of citrus bioflavonoids, and hence, their addition optimises the efficiency of Vitamin C. The combination of Vitamin C and citrus bioflavonoids boosts the antioxidant capacity of our blend, and this in turn, optimises the effect of Quercetin.